Ivanov Laboratory receives US Patent for new antibody cancer research tool

Ivanov Laboratory receives US Patent for new antibody cancer research tool

The application process started in 2015 with the publication of an article in Cancer Research journal by Ivanov’s group titled “KAP1 promotes proliferation and metastatic progression of breast cancer cells”.

The researchers looked at the expression of C2H2-type zinc finger transcription factors or ZNFs in short in breast cancer. Transcription factors are proteins that bind to DNA and regulate the expression of genes. C2H2 ZNFs form the largest family of human transcription factors. They are also extremely difficult to detect.

The researchers developed a unique antibody tool that identifies hundreds of members of C2H2 zinc finger proteins. Furthermore, they used this antibody to discover that many ZNF proteins are overexpressed in breast cancer.

Our next step would be to explore the possibility of using the antibody as a diagnostic or predictive tool for breast and potentially other types of cancer. The antibody is currently licensed to MilliporeSigma where it is available for use in research laboratories. This research tool has been referenced in several recent publications.

Contact Alexey Ivanov, PhD, with questions or for more information

  • Virtual 'March Into Mindfulness' series scheduled to begin March 1

    Virtual 'March Into Mindfulness' series scheduled to begin March 1

    March into Mindfulness to gain valuable skills in becoming a more integrated human while understanding how to navigate the current emotions of the pandemic with more strength and calmness. This free virtual series will take place from noon to 1 p.m. every Monday during the month of March.

    Read More

  • Office of Health and Wellness seeking proposals

    Office of Health and Wellness seeking proposals

    If you have a project idea related to one of the following Wellbeing Priorities, submit your proposal to amsidwell@hsc.wvu.edu by Friday, March 5, 2021.

    Read More

  • Under the Dome: February 16, 2021 Edition

    Under the Dome: February 16, 2021 Edition

    Under the Dome delivers a review of the issues being considered by the 85th West Virginia Legislature of West Virginia. It provides information on matters that affect WVU and higher education. This edition provides an update on the first week of the legislative session, Governor Justice’s State of the State address and several high-profile bills introduced during the first few days of session.

    Read More