Martinez Laboratory

Martinez with his lab group

The recent discovery of different classes of non-coding RNAs and their importance in almost every cellular process has opened a new frontier in understanding the regulation of gene expression. The main interest in my laboratory is to study the importance of non-coding RNAs, such as microRNAs (miRNAs) and large non-coding RNAs (lncRNAs), during the process of carcinogenesis in cells infected by human papillomaviruses (HPVs). Our laboratory is also interested in the importance of these non-coding RNAs in different types of cellular growth arrest such as cellular senescence (a form of irreversible growth arrest and a major tumor suppressor mechanism) and cellular quiescence (a form of reversible growth arrest important for tissue homeostasis and stem cell self-renewal).